![]() These rates make colorectal cancer one of the costliest cancers for healthcare systems. Incidence-based mortality rates of colorectal cancer in Latin America and Peru are 16.6–8.2 and 11.4–5.6 per 100,000 people, respectively. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Īccording to GLOBOCAN 2020, colorectal cancer is the third most common type of cancer globally and the fourth most common in Peru, with incidence rates of 10% and 6.6%, respectively. Publication costs for this article were supported by ecancer (UK Charity number 1176307).Ĭopyright: © the authors licensee ecancermedicalscience. Keywords: costs and cost analysis, radiation dose hypofractionation, neoadjuvant therapy, rectal neoplasms, chemoradiotherapy, short-course radiation therapyĬorrespondence to: José Fernando Robles Díaz The costs to patients using SCRT-TNT are much lower, but it is also a better option because it saves hospital resources. SCRT-TNT regimens with CAPOX reduce costs by at least 50%, while SCRT-TNT regimens with FOLFOX reduce costs by 32%.Ĭonclusion: Despite using IMRT/VMAT, SCRT-TNT is a less expensive approach for patients with RC when compared to LCRT. The indirect cost of FOLFOX regimens is twice that of the similar modality that combines irradiation and Oxaliplatin IV and Capecitabine VO (CAPOX). Administering radiotherapy in 28 3D sessions and 5 sessions of intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) sessions costs S/.2,603.88, S/.1,277.19 and S/.1,027.77, respectively. This registry outlined the direct and indirect costs of LCRT versus SCRT-TNT. Materials and Methods: In 2020–2021, a prospective registry was created to document RC patients who received neoadjuvant therapy and the costs of cancer treatments, transportation and the time patients and family members spent in the hospital. The objective of this study was to perform a cost analysis comparing SCRT-TNT versus LCRT. There are few economic assessment reports available on TNT that focus on cost analysis in a country with limited funding for healthcare systems. Background and Objectives: Conventional long-course radiotherapy (LCRT) and a new paradigm of short-course radiotherapy with total neoadjuvant therapy (SCRT-TNT) are used in locally advanced rectal cancer (RC).
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